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Elranatamab: A novel B-cell maturation T-cell engager

Shahrier Hossain1, Giada Bianchi1,2

  • 1Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Human Vaccines & Immunotherapeutics
|July 8, 2026
PubMed

B-cell maturation antigen (BCMA) is a highly expressed transmembrane receptor on malignant plasma cells, mediating cell survival. These characteristics make it an attractive target for novel cellular and immunotherapies. Elranatamab is a bispecific antibody targeting BCMA on plasma cells and CD3 on T cells. This leads to immune cell activation and the release of granzymes and perforins, with attendant killing of target cells. Overactivation of the immune system can lead to cytokine release syndrome (CRS) and immune cell associated neurotoxicity syndrome (ICANS). Compared to similar agents, elranatamab has a favorable safety profile with robust efficacy. It is currently approved for relapsed/refractory multiple myeloma with clinical trials evaluating its use in combination and in earlier lines of therapy.

Keywords:
B-cell maturation antigenElranatamabal-amyloidosisbispecific monoclonal antibodiesmultiple myelomaplasma cells

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