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Published on: July 7, 2023
Intraocular Lens Positional Instability and Refractive Prediction Error after Cataract Surgery in Eyes with Retinitis
Se Young Hong1, Richul Oh1,2, Hyun-Min Na1,2
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Korean Journal of Ophthalmology : KJO
|July 8, 2026
Summary
Patients with retinitis pigmentosa (RP) experience greater intraocular lens (IOL) instability and refractive unpredictability after surgery. These refractive errors persist even after accounting for IOL design, suggesting a direct impact of RP on visual outcomes.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Retinitis pigmentosa (RP) is a group of inherited disorders that affect photoreceptor cells.
- Intraocular lens (IOL) implantation is a common procedure following cataract surgery.
- Positional stability of the IOL is crucial for achieving optimal refractive and visual outcomes.
Purpose of the Study:
- To assess postoperative intraocular lens (IOL) positional instability in eyes with retinitis pigmentosa (RP).
- To investigate the association between IOL instability and refractive/visual outcomes in RP patients.
- To utilize anterior segment optical coherence tomography (AS-OCT) for precise IOL evaluation.
Main Methods:
- Retrospective analysis of 55 RP eyes and 83 control eyes post-phacoemulsification with in-the-bag IOL implantation.
- Quantification of IOL tilt and decentration using AS-OCT.
- Multivariable and sensitivity analyses to determine associations with RP status.
Main Results:
- RP eyes exhibited greater myopic prediction error (PE) and absolute prediction error (APE).
- RP eyes showed significantly increased IOL tilt and decentration compared to controls.
- RP status was independently associated with greater IOL tilt, decentration, myopic PE, and APE.
Conclusions:
- Eyes with retinitis pigmentosa demonstrate increased postoperative IOL positional instability and refractive unpredictability.
- While some positional differences were linked to study design imbalances, refractive prediction errors remained significant after adjusting for IOL type.
- RP appears to directly impact refractive predictability following cataract surgery.