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Updated: Jul 9, 2026
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Characterizing Extracellular Vesicles from Biological Fluids
Published on: February 28, 2025
Organoid-Derived Extracellular Vesicles: From Biogenesis and Cargo Mechanisms Toward Therapeutic Applications
Li Luo1, Wenxiang Liu1, Zhengzhao Li2
1Center for Translational Research in Clinical Medicine, Medical School, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
International Journal of Nanomedicine
|July 8, 2026
Summary
Organoid-derived extracellular vesicles are promising therapeutic agents and diagnostic tools due to their tissue-specific information. Engineering these vesicles enhances their potential for precision medicine applications.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Nanomedicine
Background:
- Organoids are 3D in vitro models mimicking human tissues, crucial for studying development and disease.
- Organoid-derived extracellular vesicles (oEVs) act as intercellular messengers, transporting functional molecules like proteins and nucleic acids.
- oEVs possess unique tissue-specific information, offering advantages in targeting precision and biocompatibility over traditional 2D culture EVs.
Purpose of the Study:
- To explore the therapeutic and diagnostic potential of organoid-derived extracellular vesicles.
- To review strategies for engineering oEVs to enhance their therapeutic efficacy and targeting capabilities.
- To discuss the application prospects of oEVs in targeted drug delivery, regenerative medicine, and biomarker identification.
Main Methods:
- Review of current research on organoid-derived extracellular vesicles.
- Analysis of engineering strategies for oEVs, including drug loading and surface modification.
- Exploration of oEV applications in disease modeling, drug delivery, and diagnostics.
Main Results:
- Organoid-derived extracellular vesicles carry specific molecular information, enabling precise targeting and enhanced biocompatibility.
- Engineering strategies show promise in improving oEV therapeutic potential and targeting capabilities.
- oEVs demonstrate potential in disease diagnosis, prognosis assessment, and as carriers in precision medicine.
Conclusions:
- Organoid-derived extracellular vesicles represent a multifunctional platform for precision medicine.
- Further research is needed to address challenges like heterogeneity and standardization for clinical translation.
- oEVs hold significant promise for targeted drug delivery, regenerative medicine, and biomarker discovery.
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