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Rare Late Cardiac Involvement Following Resected Primary Limb Dedifferentiated Liposarcoma: A Case Report.
Azin Alizadehasl1, Saeedeh Baghyari1,2, Mostafa Salimi3
1Cardio-Oncology Research Center Rajaie Cardiovascular Institute Tehran Iran.
Clinical Case Reports
|July 8, 2026
Summary
Metastatic dedifferentiated liposarcoma (DDLPS) to the heart is rare and challenging. Cardiovascular magnetic resonance (CMR) aids diagnosis, but treatment is complex, highlighting the need for multidisciplinary care in managing cardiac sarcoma.
Area of Science:
- Cardiovascular Pathology
- Oncology
- Radiology
Background:
- Dedifferentiated liposarcoma (DDLPS) is an aggressive soft tissue sarcoma.
- Cardiac involvement by DDLPS, either primary or metastatic, is exceptionally rare.
- Such cases present significant diagnostic and therapeutic challenges.
Purpose of the Study:
- To report a rare case of metastatic cardiac dedifferentiated liposarcoma.
- To illustrate the diagnostic utility of cardiovascular magnetic resonance (CMR).
- To emphasize the importance of multidisciplinary management for complex cardiac sarcomas.
Main Methods:
- Case report of a 68-year-old woman with a history of DDLPS.
- Evaluation of a mediastinal mass with pericardial involvement using cardiovascular magnetic resonance (CMR).
- Review of diagnostic and therapeutic approaches for metastatic cardiac sarcoma.
Main Results:
- The patient presented with dyspnea due to a large mediastinal mass with pericardial involvement.
- CMR revealed imaging features consistent with metastatic DDLPS.
- Surgical resection was not feasible; the patient received chemotherapy but ultimately succumbed to complications.
Conclusions:
- Metastatic cardiac DDLPS should be considered in patients with a history of soft tissue sarcoma presenting with cardiac masses.
- CMR is valuable for diagnosing cardiac malignancies.
- Multidisciplinary management is crucial for non-resectable cardiac sarcomas.