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Updated: Jul 9, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
Published on: July 13, 2019
No association between delayed graft function and BK polyomavirus infection reactivation after kidney
Thidarat Kitrungphaiboon1, Felicity Evison2, Suzy Gallier2
1Department of Nephrology, Bhumirajanagarindra Kidney Institute Hospital, Bangkok, Thailand.
Introduction:
An association between delayed graft function (DGF) and BK polyomavirus (BKPyV) DNAemia is not well defined.
Methods:
We investigated this with 1) a retrospective review of a single-center cohort analysis, and 2) a systematic review & meta-analysis of published data. Kidney transplant recipients at a single-center between 01/01/2007-30/06/2018 were analyzed. Comparative analyses were done with logistic regression models based upon clinical risk factors. Following a systematic review of published studies, meta-analysis was performed using the DerSimonian-Laird random effects model.
Results:
In our single-center analysis, we analyzed 1,770 kidney transplant recipients with median follow up 5.3 years (interquartile range 2.7-8.7 years). BKPyVDNAemia was associated with; male sex (8.3% versus 5.3% respectively, p=0.017), ABO-incompatible transplantation (10.3% versus 4.6% respectively, p=0.004) and DGF (9.0% versus 6.3% respectively, p=0.048). In a multivariate analysis, only recipient male sex and ABO-incompatible transplantation was associated with BKPyVDNAemia. In a systematic review of published literature, we identified 11 studies and performed a meta-analysis of empirical data including our Birmingham cohort data. No significant association was observed between DGF rates and BKPyVDNAemia (OR 1.00, 95% CI 0.67-1.50).
Discussion:
We did not identify any association between DGF rates and subsequent BKPyVDNAemia.
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