Targeted Follicular Delivery via Liposomal Encapsulation of Sesbania grandiflora - Enhances Hair and Scalp Health: A...

Hair fall results from disruption of the hair growth cycle, resulting in reduced hair density, thickness, and overall scalp health. With increasing interest in safer plant-based therapies, this study evaluated the safety and efficacy of a liposomal-encapsulated Sesbania grandiflora formulation 150 mg compared with placebo on hair and scalp health.

This single-center, randomized, double-blind, placebo-controlled study was conducted over 180 days (24 weeks) in adults aged 25-45 years with hair loss. Subjects were randomized 1:1 to receive once-daily liposomal Sesbania grandiflora 150 mg or placebo orally for six months, with eight scheduled visits. Outcomes included hair density, thickness, growth rate, keratin levels, hair length, anagen-telogen ratio, hair fall, hair regrowth, tensile strength, nail brittleness, laboratory parameters, and overall hair and scalp appearance assessed using calibrated bioinstrumentation and standardized methods.

The liposomal Sesbania grandiflora group demonstrated significant improvement in all outcomes by day 180. Hair density (274.88±25.05 cm²; p <0.0001), hair thickness (9.53±1.28 µm;p <0.0001), and hair growth rate (323.65±61.38 µm/day; p <0.0001). Improvements were also observed in hair length (228.18±43.71 µm; p <0.0001), anagen hairs (61.04±12.44%; p <0.0001), and telogen hairs (38.96±12.44%; p <0.0001). Keratin levels and scalp condition improved, accompanied by a reduced hair fall and enhanced hair regrowth (10.06±1.98; p <0.0001). Hair tensile strength increased significantly (35,086.09±6,374.81 g/m²; p <0.0001). Adverse events were reported during the study; however, none were considered related to the product.

SesZenBio™, a biotin- and polyphenol-rich liposomal formulation, significantly improved hair and scalp health compared with placebo, evidenced by increased hair thickness, hair density, hair length, hair growth rate, anagen hair percentage, keratin, and tensile strength, along with a reduction in hair fall The formulation was well tolerated, supporting its potential as an effective plant-based product for the improvement of hair parameters.