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Related Experiment Video

Updated: Jul 9, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Dynamic Lactate Level: An Effective Predictor of Short-Term Mortality After Type A Aortic Dissection Surgery.

Zhiyan Chen1, Yanchao Qi1, Ding Yu2

  • 1Heart Center, The First Hospital of Hebei Medical University, 050000 Shijiazhuang, Hebei, China.

Reviews in Cardiovascular Medicine
|July 8, 2026
PubMed
Summary

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Postoperative lactate levels in Type A aortic dissection (TAAD) patients predict mortality. Monitoring lactate trends in the first three days after surgery can identify patients at higher risk for adverse outcomes.

Area of Science:

  • Cardiovascular Surgery
  • Critical Care Medicine
  • Biomarker Research

Background:

  • Type A aortic dissection (TAAD) is a critical surgical emergency.
  • Elevated lactate (Lac) levels are common during TAAD surgery.
  • Early postoperative lactate changes may correlate with patient outcomes.

Purpose of the Study:

  • To investigate the relationship between early postoperative lactate levels and short-term mortality in TAAD patients.
  • To identify lactate dynamics as a predictor of mortality after TAAD surgery.
  • To evaluate lactate clearance (LC) as a prognostic marker.

Main Methods:

  • Retrospective analysis of 146 TAAD patients.
  • Lactate levels measured immediately post-surgery and on postoperative days (PODs) 1 and 3.
Keywords:
aortic dissectionlactatelactate clearancerisk factorsshort-term mortality

Related Experiment Videos

Last Updated: Jul 9, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

  • Logistic regression, ROC curves, and Cox regression used to analyze mortality risk factors.

    • Main Results:

    • Non-survivors exhibited higher lactate levels on PODs 1 and 3.
    • Lactate trend over the first 3 days was an independent mortality risk factor (HR=1.33).
    • On POD3, lactate (AUC=0.838) and LC (AUC=0.667) predicted short-term mortality.

    Conclusions:

    • Dynamic postoperative lactate changes are significantly linked to adverse outcomes in TAAD.
    • Lactate and lactate clearance on POD3 are reliable predictors of short-term mortality.
    • Lactate monitoring offers valuable prognostic information for TAAD patients.