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Gastric Juice microRNAs in Gastric Cancer: What is the Evidence?
Gerasimia D Kyrochristou1, Fotios S Fousekis2, Christina D Bali1
1Department of Surgery, University Hospital of Ioannina, 45500 Ioannina, Greece.
Background:
So far, combining gastroscopy with biopsy remains the gold-standard for screening gastric cancer. Recently, the study of circulating microRNAs (miRNAs or miRs) has yielded valuable insights into gastric cancer prognosis. However, because these molecules are common to multiple cancer types, their clinical applicability remains uncertain.
Materials And Methods:
We investigated the pertinent literature dealing with gastric juice microRNAs in gastric cancer patients. Only five original articles have investigated the feasibility of using gastric juice miRNAs as potential biomarkers to assist in screening for gastric cancer.
Results:
Gastric juice microRNAs proved correlated with high reliability, high sensitivity, high specificity and relative stability.
Conclusion:
MicroRNAs found in gastric juice may offer a promising alternative approach for gastric cancer screening without the need for biopsy. More studies are needed to reach safe conclusions. However, it seems that this novel potential biomarkers' testing is reliable and reproducible.
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