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Related Experiment Video

Updated: Jul 9, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

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Redefining Sciatic Nerve Division Patterns: Cadaveric Study Introducing a Novel Index-Based Classification for

Vandana Tiwari1, Priti Chaudhary2, Navita Aggarwal3

  • 1Associate Professor, Department of Anatomy, All India Institute of Medical Sciences, Bathinda, Punjab, India.

Maedica
|July 8, 2026
PubMed
Summary

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Sciatic nerve (SN) division shows high variability, challenging surgical procedures. A new sciatic nerve division index (SNDI) offers precise sub-classification for improved anatomical localization and procedural safety.

Area of Science:

  • Anatomy
  • Morphometrics
  • Surgical Anatomy

Background:

  • Sciatic nerve (SN) division exhibits significant anatomical variability.
  • Existing classification models are inadequate for precise sub-classification of SN bifurcation.
  • This variability poses challenges in orthopaedic, neurosurgical, and anaesthetic procedures.

Purpose of the Study:

  • Introduce a novel sciatic nerve division index (SNDI).
  • Enable precise sub-classification of SN bifurcation levels.
  • Enhance anatomical localization for improved procedural safety.

Main Methods:

  • Dissection of 58 lower limbs from 29 adult cadavers.
  • Tracing SN bifurcation beyond the piriformis muscle (Beaton and Anson Type A).
  • Subtyping bifurcation levels (AI, AII, AIII) using the SNDI morphometric tool.
Keywords:
anatomical variationclassificationcommon peroneal nervepiriformis syndrometibial nerve

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Last Updated: Jul 9, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
08:16

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

An In Vivo Murine Sciatic Nerve Model of Perineural Invasion
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Published on: April 23, 2018

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Main Results:

  • Extra-pelvic (Type A) bifurcation observed in 72.41% of limbs.
  • Mid-thigh (Type AII) bifurcation was most frequent (44.8%).
  • Proximal (Type AI) and distal (Type AIII) bifurcations occurred in 29.3% and 25.9%, respectively; non-Type A variants comprised 27.58%.

Conclusions:

  • High variability in SN division necessitates improved classification models.
  • The SNDI system enhances consistency and anatomical localization of SN bifurcation.
  • This leads to improved procedural safety and informs future research and education.