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Updated: Jul 9, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Dynamic Versus Static Cardiac Biomarker Assessment for Prognostic Stratification After Percutaneous Coronary

Nabila N Anika1,2, Mohamed K Said3, Hamza Al Balushi4

  • 1General Surgery, University of South Florida Health, Florida, USA.

Cureus
|July 8, 2026
PubMed

Insights

Serial cardiac biomarker assessment, particularly NT-proBNP, may improve risk prediction in percutaneous coronary intervention (PCI) patients compared to single measurements. Dynamic evaluation offers insights into ischemic burden and reperfusion dynamics.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Interventional Cardiology

Background:

  • Cardiac biomarkers are crucial for risk stratification in percutaneous coronary intervention (PCI).
  • Optimal timing and mode of cardiac biomarker assessment post-PCI remain unclear.
  • Current guidelines lack definitive recommendations on serial vs. single biomarker measurements.

Purpose of the Study:

  • To systematically review and evaluate the prognostic significance of serial, delta, and peak cardiac biomarker measurements versus single baseline measurements in PCI patients.
  • To compare the predictive value of different cardiac biomarkers (troponin, NT-proBNP, CK-MB) and assessment strategies.
  • To identify optimal biomarker assessment strategies for improved risk stratification in PCI.

Main Methods:

  • Systematic literature review of PubMed/MEDLINE, Scopus, and Web of Science.
  • Inclusion of nine cohort studies across diverse PCI settings (elective, primary, CTO).
  • Assessment of various biomarkers (high-sensitivity troponin, conventional troponin, NT-proBNP, CK-MB) using baseline, peak, serial, and delta strategies.

Main Results:

  • Baseline troponin levels consistently predict outcomes post-PCI.
  • Post-procedural troponin elevations show variable prognostic value, dependent on thresholds.
  • Serial assessment of N-terminal pro-B-type natriuretic peptide (NT-proBNP) enhances prognostic discrimination and reflects pathophysiologic processes.

Conclusions:

  • Dynamic biomarker assessment, especially NT-proBNP, may offer incremental prognostic value over static measurements in PCI.
  • Clinical integration of dynamic biomarker assessment requires further validation.
  • A nuanced, context-dependent approach to biomarker interpretation is supported for PCI populations.

Keywords:
cardiac biomarkersdelta biomarkermajor adverse cardiovascular eventsmyocardial injurynt-probnppercutaneous coronary interventionprognostic valuerisk stratificationserial measurementtroponin

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