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Updated: Jul 9, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Lactoferrin-Templated Silver Peroxide Nanoparticles Reinforced Core-Shell Microneedle for Diabetic Infected Wound

Jianying Hao¹, Xiang Ji¹, Xiuqiang Li¹

¹School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.

Small (Weinheim an Der Bergstrasse, Germany)

|July 8, 2026

Summary

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Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

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This summary is machine-generated.

This study presents novel lactoferrin-silver oxide nanoparticles (LF-Ag2O2 NPs) and a microneedle patch for enhanced diabetic wound healing. The system delivers sequential antibacterial and regenerative treatments, improving healing outcomes.

Area of Science:

Biomaterials Science
Nanotechnology
Regenerative Medicine

Background:

Diabetic wounds present significant healing challenges due to infection and inflammation.
Existing nanosilver antibacterial agents face limitations in preparation, stability, and biocompatibility.

Purpose of the Study:

To develop improved lactoferrin-silver oxide nanoparticles (LF-Ag2O2 NPs) for enhanced antibacterial activity.
To create a core-shell microneedle patch for programmed sequential delivery of LF-Ag2O2 NPs and fibroblast growth factor (FGF) for diabetic wound treatment.

Main Methods:

Synthesized LF-Ag2O2 NPs using a one-step biomimetic mineralization method with lactoferrin (LF) as a dispersant.
Designed a core-shell microneedle patch with a layered drug loading strategy for controlled release.

Keywords:

LF‐Ag2O2 nanoparticles antibacterial effect core–shell microneedle diabetic wound healing sequential therapy

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Last Updated: Jul 9, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Investigated the synergistic antibacterial effects and the regenerative potential of the microneedle patch in a diabetic wound model.

Main Results:

LF-Ag2O2 NPs exhibited improved dispersibility, stability, and biocompatibility compared to traditional agents.
The microneedle patch demonstrated rapid release of LF-Ag2O2 NPs for bacterial elimination and subsequent slow release of FGF for tissue regeneration.
The system effectively disrupted the infection-inflammation cycle and accelerated diabetic wound healing.

Conclusions:

The developed LF-Ag2O2 NPs and microneedle patch offer a promising strategy for managing complex diabetic wounds.
This programmed drug delivery system enhances wound healing by combining antibacterial and regenerative therapeutic actions.