Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of a Combined Zumba and Video Game-Based Cognitive Intervention on Cognitive Function Among Older Adults in Klang Valley, Malaysia: Semirandomized Trial.

JMIR aging·2026
Same author

What influences the decision by primary care doctors to recommend cancer screening? A qualitative evidence synthesis.

BMJ open·2026
Same author

Assessing empathy in adults: A Malay language validation and measurement invariance of the Empathy Quotient (M-EQ).

PloS one·2026
Same author

The Feasibility of Smartwatch Micro-Ecological Momentary Assessment for Tracking Eating Patterns of Malaysian Children and Adolescents in the South-East Asian Community Observatory Child Health Update 2020: Cross-Sectional Study.

Journal of medical Internet research·2026
Same author

Community-Based BMI Screening for Overweight and Obesity in Adults Aged 35 Years and Older in Malaysia: Regression Discontinuity Analysis.

JMIR public health and surveillance·2025
Same author

Renal Denervation in Asia: 2025 Asia Renal Denervation Consortium (ARDeC) Consensus Statement Endorsed by the Hypertension Cardiovascular Outcome Prevention and Evidence in Asia (HOPE Asia) Network.

Hypertension (Dallas, Tex. : 1979)·2025

Related Experiment Video

Updated: Jul 9, 2026

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
07:01

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

Published on: September 20, 2020

An Evidence-Based Cognitive Stimulation and Physical Activity Intervention to Delay Aging-Related Decline: Protocol

Yook Chin Chia1,2,3, Eden Ngah Den Low3,4, Michael Jenkins5

  • 1Department of Clinical Medicine and Surgery, Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, Bandar Sunway, Selangor, Malaysia.

JMIR Research Protocols
|July 8, 2026
PubMed
Summary

This study investigates multi-component interventions to slow cognitive decline in aging Malaysian adults. Findings aim to enhance healthy aging strategies and inform policy for improved quality of life.

Keywords:
agingbiological and neurocognitive markerscognitive agingcognitive declinehealthy agingintervention-control studyphysical decline

Related Experiment Videos

Last Updated: Jul 9, 2026

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
07:01

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

Published on: September 20, 2020

Area of Science:

  • Gerontology and Public Health
  • Neuroscience
  • Cognitive Psychology
  • Health Economics

Background:

  • Increasing longevity presents challenges of age-related decline and reduced independence, particularly in Asian populations.
  • Existing health assessments often fail due to cultural and educational gaps in Western-designed instruments.
  • Addressing age-related cognitive decline is crucial for individual well-being and societal productivity.

Purpose of the Study:

  • To evaluate the 4-year effectiveness of cognitive, physical, or combined interventions in slowing aging-related cognitive decline.
  • To assess changes in brain structure, function, and salivary biomarkers associated with aging.
  • To conduct a cost-benefit analysis of the implemented interventions.

Main Methods:

  • A randomized controlled trial involving 400 Malaysian adults aged 60+.
  • Intervention packages included cognitive stimulation, physical activity, or a combination thereof.
  • Multidisciplinary assessments covered psychology, neuroscience (MRI, EEG), decision-making, economics, and salivary biomarkers.

Main Results:

  • Primary outcomes include changes in cognitive scores (MoCA), behavioral measures, neuroimaging data (EEG, MRI), and salivary biomarkers (lactoferrin, CRP, telomere length).
  • Economic impact assessed via cost-benefit analysis.
  • Intervention phase ongoing; initial results anticipated in 2026.

Conclusions:

  • The study will provide a multidisciplinary evaluation of interventions for healthy aging.
  • Expected to yield evidence-based insights to improve quality of life for older adults.
  • Findings aim to influence policymaking for better aging support.