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Prevalence of Atopic Disease in Pediatric Patients with Hypermobile Ehlers-Danlos Syndrome

Jordan T Jones1, Kathleen G Click2, Ashley Lytch1

  • 1Children's Mercy Kansas City, Kansas City, Missouri, USA.

Pediatric Allergy, Immunology, and Pulmonology
|July 8, 2026
PubMed

Insights

Pediatric patients with hypermobile Ehlers-Danlos syndrome (hEDS) show a higher prevalence of atopic conditions like allergic rhinitis and asthma compared to the general US pediatric population. Healthcare providers should monitor for these allergies in children with hEDS.

Area of Science:

  • Pediatric Allergy and Immunology
  • Genetics and Rare Diseases
  • Connective Tissue Disorders

Background:

  • Ehlers-Danlos syndromes (EDS) are connective tissue disorders causing skin laxity and joint hypermobility.
  • EDS is linked to various comorbidities requiring multidisciplinary care.
  • While adults with EDS have higher rates of atopic conditions, pediatric prevalence remains understudied.

Purpose of the Study:

  • To determine the prevalence of atopic conditions (allergies, asthma, atopic dermatitis) in pediatric patients with hypermobile EDS (hEDS).
  • To compare these prevalences to the general United States pediatric population.

Main Methods:

  • A convenience sample of 149 pediatric patients (aged 8-22) diagnosed with hEDS and atopic disease was analyzed.
  • Data on atopic conditions and medication use were systematically reviewed.

Main Results:

  • The study included predominantly female (85%) and Caucasian (89%) patients with a mean age of 15.5 years.
  • Prevalence rates were higher for allergic rhinitis (46%), medication allergies (44%, notably antibiotics), and asthma (39%, mostly mild intermittent) compared to the general US pediatric population.
  • Atopic dermatitis prevalence was not significantly different from the general population.

Conclusions:

  • Pediatric patients with hEDS exhibit an increased prevalence of atopic conditions compared to their non-hEDS counterparts in the US.
  • Healthcare providers should proactively screen for and monitor atopic and allergic conditions in pediatric hEDS patients.
  • Consultation with allergy and pulmonology specialists is recommended for symptomatic pediatric patients with hEDS.

Keywords:
Ehlers–Danlos syndromeallergyasthmaatopic dermatitis

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