Related Experiment Video
Updated: Jul 9, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
History and future of RNA medicines
Alain Hovnanian1, Guillaume Mondon2, Matthias Titeux2
1Laboratory of genetic skin diseases, Institut Imagine, Unité Mixte de Recherche 1163, Inserm, Université Paris Cité, Paris, France; Department of Genomic Medicine of Rare Diseases, Assistance Publique - Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, France.
Abstract:
RNA therapeutics are a versatile class of medicines that exploit different types of RNA molecules to prevent or treat a wide spectrum of diseases. Compared with traditional small-molecule drugs, protein drugs, or gene therapies, these therapies offer notable advantages, including faster, less expensive development, and simplified manufacturing. The field encompasses multiple modalities, such as antisense oligonucleotides, small interfering RNAs, microRNAs, mRNAs, and aptamers. The success of mRNA vaccines against SARS-CoV-2 has accelerated research and clinical translation of RNA approaches for conditions with limited treatment options, including chronic wounds, aggressive metastatic melanoma, and autoimmune and genetic skin diseases.
More Related Videos
12:03Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
11:57Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
Published on: April 21, 2016
Related Concept Videos
Experimental RNAi
Microorganisms in Medicine and Therapeutics
RNA Interference
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Interference
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Types of RNA
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA
RNA Performs Diverse...