Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
Vascular Resistance01:20

Vascular Resistance

Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk stratification of outcomes after coronary artery bypass grafting in ischemic cardiomyopathy with symptomatic heart failure.

Journal of cardiothoracic surgery·2026
Same author

Optimal surgical timing for atrial functional mitral regurgitation based on preoperative diuretic requirement: a retrospective cohort study.

Journal of thoracic disease·2026
Same author

Untreated mild-moderate mitral regurgitation after isolated aortic valve replacement for aortic stenosis.

Journal of cardiothoracic surgery·2026
Same author

Nanomicelle-Based Multi-mRNA Delivery Promotes Cardiac Repair After Myocardial Infarction.

Small science·2026
Same author

Salvage Third-Patch Repair for Left Ventricular Free Wall Rupture After Double-Patch Septal Reconstruction.

Annals of thoracic surgery short reports·2026
Same author

Valve Oversizing and Geometric Factors in Structural Valve Deterioration After Pulmonary Valve Replacement.

The Annals of thoracic surgery·2026

Related Experiment Video

Updated: Jul 9, 2026

Modified Langendorff Perfusion for Extended Perfusion Times of Rodent Cardiac Grafts
06:22

Modified Langendorff Perfusion for Extended Perfusion Times of Rodent Cardiac Grafts

Published on: June 14, 2024

Side Port Resistance Limits Distal Perfusion Flow.

Takeshi Matsumoto1, Shin Yajima2, Daisuke Yoshioka2

  • 1From the Department of Clinical Engineering, The University of Osaka Hospital, Suita, Osaka.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|July 8, 2026
PubMed
Summary

Introducer sheaths with side ports used for limb perfusion during extracorporeal membrane oxygenation (ECMO) limit flow. Catheters without side ports may offer better antegrade perfusion to prevent limb ischemia.

Keywords:
MICSVA-ECMOdistal perfusionside port

More Related Videos

Porcine Normothermic Isolated Liver Perfusion
07:32

Porcine Normothermic Isolated Liver Perfusion

Published on: June 9, 2023

Related Experiment Videos

Last Updated: Jul 9, 2026

Modified Langendorff Perfusion for Extended Perfusion Times of Rodent Cardiac Grafts
06:22

Modified Langendorff Perfusion for Extended Perfusion Times of Rodent Cardiac Grafts

Published on: June 14, 2024

Porcine Normothermic Isolated Liver Perfusion
07:32

Porcine Normothermic Isolated Liver Perfusion

Published on: June 9, 2023

Area of Science:

  • Cardiovascular Surgery
  • Medical Devices
  • Extracorporeal Life Support

Background:

  • Femoral arterial cannulation for peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) and cardiac surgery can cause lower limb ischemia.
  • Introducer sheaths with side ports are commonly used to facilitate antegrade limb perfusion, but their efficacy is debated.

Purpose of the Study:

  • To compare the flow performance and pressure loss of introducer sheaths with side ports versus a catheter without a side port under simulated extracorporeal membrane oxygenation conditions.
  • To identify the structural components responsible for flow resistance in perfusion devices.

Main Methods:

  • Evaluated flow performance and pressure loss of two introducer sheaths with side ports and one catheter without a side port.
  • Conducted experiments using an extracorporeal membrane oxygenation circuit with inlet pressures ranging from 50-300 mm Hg.
  • Measured pressure loss specifically across the side port region.

Main Results:

  • Introducer sheaths with side ports demonstrated attenuated flow augmentation and early saturation with increasing perfusion pressure.
  • The catheter without a side port exhibited a linear pressure-flow relationship without saturation.
  • The side port region accounted for approximately 70% of the total pressure loss in the 5Fr sheath, irrespective of perfusion pressure.

Conclusions:

  • The side port structure is a primary resistance factor limiting antegrade perfusion.
  • Conventional side port introducer sheaths may not adequately resolve limb ischemia complications.
  • Catheters lacking side ports may be a superior option for maintaining adequate antegrade perfusion.