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Updated: Jul 9, 2026
05:41
Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Combinatorial cancer therapy mediated by hydroxyapatite nanoparticles: a comprehensive review
Khadija Fatima1, Iqra Fatima Khan2, Sidra Fatima Khan2
1Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Medical Oncology (Northwood, London, England)
|July 8, 2026
Summary
Hydroxyapatite nanoparticles (HANPs) offer versatile cancer nanomedicine solutions for drug delivery and therapy. These biocompatible platforms show promise in combined treatments and theranostics, enhancing efficacy and reducing toxicity.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Hydroxyapatite nanoparticles (HANPs) are biocompatible and structurally similar to bone apatite.
- HANPs possess tunable surface chemistry and ion substitution capabilities for drug delivery.
- Their versatility makes them promising in cancer nanomedicine.
Purpose of the Study:
- To provide a comprehensive overview of hydroxyapatite nanoparticle-mediated combinatorial cancer therapies.
- To highlight the multifunctional roles of HANPs in drug delivery, imaging, and therapy.
- To discuss the potential of HANPs as theranostic agents in precision oncology.
Main Methods:
- Review of literature on HANPs in cancer nanomedicine.
- Analysis of HANP integration with chemotherapy, immunotherapy, and photothermal/photodynamic therapy.
- Evaluation of HANPs in multimodal imaging for theranostic applications.
Main Results:
- HANPs demonstrate synergistic effects when combined with various cancer treatments, enhancing antitumor efficacy.
- HANPs show potential as drug carriers, photothermal agents, and immunomodulators.
- HANPs can function as theranostic agents, combining diagnostic and therapeutic capabilities.
Conclusions:
- Hydroxyapatite nanoparticles (HANPs) are intelligent, biocompatible nanoplatforms for simultaneous cancer diagnosis and therapy.
- Significant preclinical progress has been made, but challenges in scalability and clinical translation remain.
- Future research should focus on long-term biosafety and clinical application of HANPs in precision oncology.
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