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Related Concept Videos

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...

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Related Experiment Video

Updated: Jul 9, 2026

Laparoscopic Common Bile Duct Exploration in Patients with a Previous History of Biliary Tract Surgery
07:36

Laparoscopic Common Bile Duct Exploration in Patients with a Previous History of Biliary Tract Surgery

Published on: February 10, 2023

Risk Factors Associated with Recurrent Biliary Obstruction After Endoscopic Bilioduodenal Double Stenting.

Mitsuru Sugimoto1, Tadayuki Takagi2, Rei Suzuki2

  • 1Department of Gastroenterology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima Prefecture, Fukushima, Japan. kita335@fmu.ac.jp.

Digestive Diseases and Sciences
|July 8, 2026
PubMed
Summary

Recurrent biliary obstruction (RBO) after endoscopic bilioduodenal double stenting for malignant bilioduodenal obstruction (MBDO) is linked to stent placement oral to the duodenal stricture. Chemotherapy may also increase RBO risk, warranting careful treatment selection.

Keywords:
ERCP-guided biliary drainageEUS-guided biliary drainageEndoscopic bilioduodenal double stentingTime to recurrent biliary obstruction

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Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
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Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Published on: March 25, 2022

Related Experiment Videos

Last Updated: Jul 9, 2026

Laparoscopic Common Bile Duct Exploration in Patients with a Previous History of Biliary Tract Surgery
07:36

Laparoscopic Common Bile Duct Exploration in Patients with a Previous History of Biliary Tract Surgery

Published on: February 10, 2023

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
07:44

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Published on: March 25, 2022

Area of Science:

  • Gastroenterology
  • Oncology
  • Interventional Endoscopy

Background:

  • Malignant bilioduodenal obstruction (MBDO) often requires endoscopic bilioduodenal double stenting.
  • Maintaining biliary stent patency is crucial for preventing cholangitis and enabling continued cancer treatment.
  • Factors influencing recurrent biliary obstruction (RBO) in MBDO patients are not fully understood.

Purpose of the Study:

  • To identify risk factors associated with RBO in patients undergoing endoscopic bilioduodenal double stenting for MBDO.

Main Methods:

  • A retrospective analysis of 55 patients with MBDO who underwent endoscopic bilioduodenal double stenting.
  • Patient characteristics, device usage, and endoscopic procedure details were assessed.
  • A Fine and Gray competing risk model was employed for multivariate analysis.

Main Results:

  • Biliary stenting positioned oral to the duodenal stricture significantly increased the risk of RBO (HR 2.98).
  • Chemotherapy was also found to be significantly associated with RBO (HR 3.74).
  • Transpapillary drainage was performed in 35 patients, and endoscopic ultrasound-guided biliary drainage in 20.

Conclusions:

  • Stent placement oral to the duodenal stricture is a significant risk factor for RBO in MBDO patients.
  • The association between chemotherapy and RBO requires cautious interpretation but suggests a potential link.
  • Consideration of alternative procedures like gastrojejunostomy for patients with oral-side biliary stenting may mitigate RBO incidence.