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Botryolides F and G from the Fungus Bartalinia robillardoides with Anthelmintic Activity
Coralie Pavesi1, Victor Flon2, Frederic Fercoq1
1Unité Molécules de Communication et Adaptation des Micro-organismes, UMR 7245, Muséum National d'Histoire Naturelle, CP 54, 57 rue Cuvier, 75005 Paris, France.
None:
The chemical investigation of the fungusBartalinia robillardoides CBS 122686 led to the isolation of two new decarestrictines bearing an unusual three-carbon unit appended to the polyketide moiety and named Botryolides F and G. The compounds were structurally characterized, and their absolute configurations were determined through a combination of spectroscopic methods, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) analyses. Botryolide G was assessed for anthelmintic activity and exhibited promising efficacy at a concentration of 100 μg/mL, with no significant cytotoxicity observed.
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Anthelminthic Agents
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