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Updated: Jul 9, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Predicting the course of chronic rhinosinusitis in young children-5-year prospective study

Ł Dobrakowski1, M Kalisiak1, J Majak1

  • 1Department of Pediatric Pulmonology, Medical University of Lodz, Lodz, Poland.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|July 8, 2026
PubMed

Insights

Predicting chronic rhinosinusitis (CRS) persistence and house dust mite allergy (AR-HDM) in preschoolers is challenging. Higher baseline quality of life scores and ILC-2 cells predict CRS persistence, while food allergy history and allergic symptoms predict AR-HDM.

Area of Science:

  • Pediatric Allergy and Immunology
  • Otorhinolaryngology
  • Immunology

Background:

  • Predicting chronic rhinosinusitis (CRS) course and house dust mite (HDM) sensitization in preschoolers is difficult.
  • Early identification of HDM-induced allergic rhinitis (AR-HDM) and CRS persistence predictors is needed.

Purpose of the Study:

  • Identify early clinical characteristics of AR-HDM in preschoolers.
  • Determine predictors for CRS persistence.

Main Methods:

  • Prospective 5-year follow-up of 133 children (4-8 years) with CRS symptoms.
  • Developed a multivariate logistic regression model using clinical and multi-omics data from preschool age.
  • Assessed predictors for CRS persistence and AR-HDM diagnosis at school age.

Main Results:

  • CRS persisted in 35% of 117 children completing follow-up.
  • Higher baseline Sinus and Nasal Quality of Life Survey (SN-5) scores (>3.6) increased persistent CRS risk (OR=3.41).
  • ILC-2 cells in nasal samples and a history of food allergy (OR=3.87) plus prominent allergic symptoms (OR=3.96) predicted AR-HDM.

Conclusions:

  • Elevated SN-5 scores and nasal ILC-2 cells predict CRS persistence.
  • Combined history of food allergy and higher allergy-related SN-5 scores predict HDM allergy in preschoolers.
  • Early prediction enables timely allergen immunotherapy initiation for allergic children.
Abstract

Keywords:
AITallergic rhinitischronic rhinosinusitishouse dust mites

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