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Updated: Jul 10, 2026

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

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A telomerase-SUCLG2 signaling axis drives drug resistance by protecting persister cells

Yu Liu1, Kejia Zhao2, Binbin Hu3

  • 1Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Chengdu, Sichuan 610041, China; Faculty of Dentistry, The University of Hong Kong, Sai Ying Pun 999077, Hong Kong The Hong Kong Special Administrative Region (HKSAR).

Cell Reports
|July 8, 2026
PubMed

Keywords:
6-thio-dGCP: cancerCP: cell biologySUCLG2adaptive resistancedrug-tolerant persister cellstargeted therapytelomerase

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