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![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Mechanochemical Sulfur-Phenolate Exchange Click Reactions
Zitong Hao1, Lanping Meng1, Yaxin Wang1
1School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, P. R. China.
None:
In the evaluation of the sustainability of efficient reactions like click reactions, the use of solvents is often overlooked. This work introduces a solvent-free, fast, and eco-friendly mechanochemical approach to the sulfur(VI)-phenolate exchange reaction (SuPhenEx), demonstrating its efficiency through the reactions of 4-nitrophenyl sulfonate esters with a range of phenols, saturated alcohols, primary and secondary amines, and anilines in high yields. Furthermore, several gram-scale syntheses highlight its potential for broader applications in green chemistry.
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