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Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Sulfur(IV)-Mediated Modular Synthesis of γ-Aryl-β-Amino-α,β-Unsaturated Carbonyl Compounds
Wenpeng Lu1, Zhen Zhang1, Cheng Ma1
1Department of Chemistry, Zhejiang University, 20 Yugu Road, HangZhou 310027, China.
None:
A regioselective aminoacylation cascade of propargyl arylsulfonium salts with N-acylsulfonamides enables the generation of imino-substituted sulfur ylides I, which could conduct an acid-catalyzed aromatic [3,3]-sigmatropic rearrangement. This sulfur(IV)-mediated procedure provides a facile approach for the modular synthesis of a variety of γ-aryl-β-amino-α,β-unsaturated carbonyl compounds.
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