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Closing the Loop: A Custom Artificial Intelligence Agent to Improve Detection of Radiologist Follow-Up
Alex Treacher1, Brett Moran2, Molly Case3
1Principal Data and Applied Scientist, Data Science, Parkland Center for Clinical Innovation, Dallas, TX, USA.
NEJM Catalyst Innovations in Care Delivery
|July 8, 2026
Summary
An artificial intelligence (AI) agent significantly improved identifying missed diagnostic opportunities in radiology reports. This AI tool enhances patient safety by ensuring follow-up care is scheduled and completed.
Area of Science:
- Medical Informatics
- Artificial Intelligence in Healthcare
- Diagnostic Error Reduction
Background:
- Missed diagnostic opportunities are a critical subset of diagnostic errors, often stemming from failures in follow-up care management.
- Large health systems face amplified challenges in managing radiologist follow-up recommendations due to reliance on electronic health record (EHR) templates.
- Suboptimal use of EHR macros can lead to missed notifications and negatively impact patient care.
Purpose of the Study:
- To develop and implement a custom artificial intelligence (AI) agent to enhance the identification and management of follow-up recommendations in radiologist notes.
- To serve as an additional safety net within the digital health workflow to prevent missed diagnostic opportunities.
- To improve the integration of actionable findings for patient outreach and scheduling.
Main Methods:
- Developed a custom AI agent utilizing a pretrained large language model to review radiologist notes, specifically clinical impressions.
- The AI agent was designed to extract and standardize key follow-up details, integrating them into the digital health workflow.
- Model performance was evaluated on 10,000 radiologist notes and during 3 months of production use (over 120,000 studies).
Main Results:
- The AI agent achieved over 97% balanced accuracy in identifying notes requiring follow-up, flagging 6.18 times more cases than the existing system.
- Demonstrated over 94% accuracy in characterizing follow-up timing, recommended procedures, and underlying abnormalities.
- Enabled more reliable patient identification for follow-up and improved workflow integration for patient outreach.
Conclusions:
- Implementation of an AI agent as a safety net significantly improved the detection of missed diagnostic opportunities in radiology.
- The AI agent accurately extracted and standardized crucial details, aiding patient outreach and scheduling processes.
- This AI-driven approach enhances the reliability of follow-up care, optimizing patient outcomes in high-volume settings.
