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Related Concept Videos

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Related Experiment Video

Updated: Jul 10, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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Integrative Chemical Genetics Platform Identifies Condensate Modulators Linked to Neurological Disorders.

Dylan Poch1, Chandrayee Mukherjee1, Sunanda Mallik1

  • 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.

Molecular Biology of the Cell
|July 8, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed CondenScreen, a new platform to find drugs targeting biomolecular condensates implicated in neurological disorders. This approach identified compounds preventing condensate accumulation and linked condensate abundance to genes involved in neurodevelopmental disorders.

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Rapid Identification of Chemical Genetic Interactions in Saccharomyces cerevisiae
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Published on: April 5, 2015

Area of Science:

  • Neuroscience
  • Biochemistry
  • Genetics

Background:

  • Dysregulation of biomolecular condensates is linked to neurological disorders.
  • Systematic identification of condensate modulators is challenging.

Purpose of the Study:

  • To develop and validate CondenScreen, a high-content screening platform for identifying modulators of biomolecular condensates.
  • To investigate the role of nuclear condensates in neurodevelopmental disorders.

Main Methods:

  • Utilized MLF2 as a condensate biomarker.
  • Integrated high-content screening with bioinformatic analysis.
  • Performed chemical screening (1,760 compounds) in a DYT1 dystonia model.
  • Conducted a genome-wide CRISPR/Cas9 screen.
  • Employed machine learning and confocal imaging for phenotype analysis.

Main Results:

  • Validated CondenScreen for condensate-targeted drug discovery.
  • Identified compounds preventing MLF2 reporter accumulation in nuclear envelope condensates.
  • Correlated nuclear condensate abundance with genes implicated in microcephaly and other neurodevelopmental disorders.
  • RNF26 deletion induced nuclear envelope condensates mimicking torsin deficiency.

Conclusions:

  • CondenScreen offers a scalable platform for identifying biomolecular condensate modulators.
  • Established a link between nuclear condensate accumulation and genes associated with neurodevelopmental disorders.