Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...

Venous Thrombosis I: Introduction

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Venous Thrombosis IV: Nursing Management

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...

Varicose Veins I: Introduction

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

T-Cell Lymphoma With Sarcoid-Like Reaction and Secondary Myelofibrosis: A Unique Case Report and Literature Review.

Case reports in hematology·2026

Same author

HER2-Ultralow: Prevalence, Characteristics, and Treatment Choices Among Advanced Breast Cancer Patients With Tumors Initially Scored as IHC 0.

The breast journal·2026

Same author

Involvement of the external ear by inflammatory skin diseases.

Clinics in dermatology·2026

Same author

Benign tumors of the auricle and the external auditory canal.

Clinics in dermatology·2026

Same author

Pathology Foundation Models: Evolution, Current Landscape, Challenges and Opportunities from a Technical and Clinical Perspective.

Bioengineering (Basel, Switzerland)·2026

Same author

Cardiac sarcoidosis presenting as sustained ventricular tachycardia mimicking arrhythmogenic right ventricular cardiomyopathy.

HeartRhythm case reports·2026

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg

Published on: November 19, 2019

Subclinical Venous Injury in Transvenous Lead Extraction: Histological Correlation With Clinical Risk Factors.

Azalfa U Lateef¹, Ufuk Vardar², Alex Hochwald²

¹Department of Medicine, Mayo Clinic, Jacksonville, Florida, USA.

Journal of Cardiovascular Electrophysiology

|July 8, 2026

Summary

This summary is machine-generated.

Subclinical vascular injury, indicated by elastin positivity, is common after transvenous lead extraction (TLE) but does not predict adverse outcomes. This reinforces the safety of TLE in experienced centers.

Keywords:

cardiac implantable electronic devices elastin risk stratification lead dwell time pocket infections transvenous lead extractions vascular injury vascular injuryvascular injuryvascular injury

More Related Videos

Venous Thrombosis Assay in a Mouse Model of Cancer

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Related Experiment Videos

Last Updated: Jul 10, 2026

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg

Published on: November 19, 2019

Venous Thrombosis Assay in a Mouse Model of Cancer

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Area of Science:

Cardiology
Vascular Surgery
Histopathology

Background:

Transvenous lead extraction (TLE) is a frequent and generally safe procedure.
Procedural complexity and risks in TLE can be influenced by various clinical and procedural factors.

Purpose of the Study:

To identify clinical and procedural factors linked to subclinical vascular injury during TLE.
To assess the clinical significance of histologic evidence of vascular injury, specifically elastin positivity on extracted leads.

Main Methods:

Analysis of 92 leads extracted from 49 patients with a lead dwell time of at least one year.
Histological examination using Verhoeff-Van Gieson staining to detect elastin presence.
Calculation of established extraction risk scores to evaluate their predictive capability for subclinical vascular injury.

Main Results:

51% of extracted leads showed elastin positivity, indicating subclinical vascular injury.
No independent predictors for elastin presence were identified, including patient demographics or lead dwell time.
Existing risk scoring systems (CCF, EROS, MB, SAFeTY, LECOM) did not predict elastin presence.

Conclusions:

Subclinical venous injury is prevalent after TLE but does not correlate with adverse clinical outcomes.
TLE procedures conducted in experienced centers demonstrate a favorable safety profile.
Further research in larger patient cohorts is necessary to fully understand the clinical utility of detecting subclinical vascular injury.