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Updated: Jul 10, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Engineering AaADH1 for enhanced catalytic efficiency and solubility via substrate tunnel modulation.

Chenyu Wang1, Xiao Feng2, Lixia Zong3

  • 1NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei 063210, China.

Enzyme and Microbial Technology
|July 8, 2026
PubMed
Summary

Protein engineering enhanced Artemisinic alcohol dehydrogenase 1 (AaADH1) for artemisinic acid production. Key mutations improved enzyme activity and expression, paving the way for industrial applications.

Keywords:
Alanine scanningArtemisinic alcohol dehydrogenaseCatalytic efficiencyMolecular Dynamics SimulationSubstrate Tunnel

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