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Updated: Jul 10, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
Gene dosage differences and non-linear impacts on complex traits
1Genomic Medicine Center, Children's Mercy Research Institute, Children's Mercy Hospital, Kansas City, MO, USA; Department of Pediatrics, School of Medicine, University of Missouri-Kansas City (UMKC), Kansas City, MO, USA.
None:
Large differences in gene dosage are usually associated with opposite phenotypic effects but show a bias toward one direction in aggregate genome wide. Milind et al. suggest that this is explained by differences in regulatory mechanisms by which genes influence phenotypes and by the increased selective pressures acting on a subset of genes.
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