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Shear Assay Protocol for the Determination of Single-Cell Material Properties
Published on: May 19, 2023
Tissue mechanopathology of cancer
Johanna Ivaska1, Sarah Sale2, Alpha S Yap2
1Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; Department of Life Technologies, University of Turku, Turku, Finland.
Abstract:
Cancers are complex cellular communities comprising tumor cells and their microenvironment. Recent advances in cancer biology have emerged from efforts to analyze tumors as tissues, in which emergent properties arise as tumor cells interact with one another, their microenvironment, and the host tissue. In this review, we consider interactions involving mechanical forces and mechanosignaling pathways that detect changes in physical inputs to regulate cellular behavior. This rapidly developing field provides perspectives for understanding cancer biology and tumor interactions with the host ecosystem.
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