Related Experiment Video
Updated: Jul 10, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Role of Genetics in Gastric Malignancy: Screening, Prevention and Treatment
Rui Zheng-Pywell1, Perry Shen2
1Department of Surgical Oncology, Atrium Health Wake Forest Baptist, Winston-Salem, NC, USA.
Abstract:
There are 3 known hereditary gastric cancers that contribute to 1% to 3% of all gastric malignancies: hereditary diffuse gastric cancer, gastric adenocarcinoma and proximal polyposis of the stomach, and familial intestinal gastric cancer. Additional hereditary cancer syndromes also contribute to increased lifetime risks of gastric malignancies: hereditary nonpolyposis colorectal cancer, familial adenomatous polyposis, Peutz-Jeghers, Li-Fraumeni, and juvenile polyposis syndrome. Germline mutations in DNA damage repair genes may be contributing to the pathogenesis of gastric cancer and may be a target for future therapeutic modalities.
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