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Non-Hodgkin Lymphoma Presenting as Peritoneal Lymphomatosis: A Case Report
Abraham Edgar Gracia-Ramos1, Martín Galván-Rodríguez2, Edith Aurora Escobar-Cázares2
1Department of Internal Medicine, Hospital General, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico. dr.gracia.dmm@gmail.com.
Clinical Medicine & Research
|July 8, 2026
Summary
Peritoneal lymphomatosis (PL), a rare extranodal non-Hodgkin lymphoma (NHL), involves lymphoma spread in the peritoneum. Early diagnosis via histology and immunohistochemistry is crucial for effective treatment and improved patient outcomes.
Area of Science:
- Oncology
- Pathology
Background:
- Peritoneal lymphomatosis (PL) is an uncommon manifestation of extranodal non-Hodgkin lymphoma (NHL).
- It is characterized by the infiltration of lymphoma cells within the peritoneal cavity.
Purpose of the Study:
- To present a case of diffuse large B-cell lymphoma with peritoneal involvement.
- To highlight the diagnostic challenges and importance of histological confirmation in PL.
Main Methods:
- Case presentation of a 43-year-old female.
- Diagnostic workup included imaging (CT scan), cytology, surgical laparoscopy with tissue biopsy.
- Histological and immunohistochemical analysis confirmed the diagnosis.
Main Results:
- Imaging showed diffuse peritoneal and omental thickening, mesenteric lymphadenopathy, and jejunal wall thickening.
- Ascitic and pleural fluid cytology were negative for malignant cells.
- Histopathology confirmed diffuse large B-cell lymphoma involving the peritoneum.
Conclusions:
- Peritoneal lymphomatosis is often an aggressive, high-grade NHL subtype.
- Clinical awareness and prompt diagnosis through tissue analysis are vital.
- Effective treatment strategies depend on accurate and early diagnosis.
