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Updated: Jul 10, 2026

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Published on: October 31, 2019

Microbial biomarkers for OPMD progression.

Jing-Wen Li¹, Yujue Wang², Akhilanand Chaurasia³

¹Faculty of Dentistry, the University of Hong Kong, Hong Kong.

Advances in Immunology

|July 8, 2026

Summary

This summary is machine-generated.

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The oral microbiome may help predict oral potentially malignant disorder (OPMD) progression to oral squamous cell carcinoma (OSCC). Integrating multi-omics data offers a robust approach for developing adjunctive clinical tools.

Area of Science:

Oral oncology
Microbiome research
Biomarker discovery

Background:

Oral potentially malignant disorders (OPMDs) have variable progression risks to oral squamous cell carcinoma (OSCC).
Current diagnostic methods lack sufficient predictive power for OPMD progression.
The oral microbiome's role in OPMD progression is under investigation.

Purpose of the Study:

To evaluate the oral microbiome as a source of predictive biomarkers for OPMD progression.
To explore multi-omics approaches for enhanced mechanistic interpretability and robustness.

Main Methods:

Review of current evidence on oral microbiome alterations in OPMDs and OSCC.
Discussion of limitations including overlapping microbial structures and confounding factors.

Keywords:

Malignant transformation Metabolomics Microbial biomarkers Multi-omics Oral dysbiosis Oral potentially malignant disorders (OPMDs)Oral squamous cell carcinoma (OSCC)Risk enrichment

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Last Updated: Jul 10, 2026

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Published on: October 31, 2019

Advocacy for an ecology-driven, multi-omics approach integrating taxonomy, metabolomics, and metaproteomics.

Main Results:

OPMDs and OSCC are associated with microbial dysbiosis, shifting towards anaerobic and away from health-associated taxa.
Translating microbial signatures into clinical practice is challenging due to overlapping states and confounders.
The causal role of dysbiosis (driver vs. consequence) remains debated.

Conclusions:

Microbiome-informed tools show promise as adjunctive aids for clinical triage and risk stratification.
A multi-omics approach is crucial for overcoming current limitations and achieving mechanistic insight.
Rigorous validation in prospective cohorts is essential for clinical utility.