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Updated: Jul 10, 2026

Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis
08:20

Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis

Published on: June 2, 2022

[Autoimmune limbic encephalitis with concurrent positivity for Caspr2 and GFAPα antibodies]

Akiko Hamamoto1, Tomohito Nakano1, Hisae Sumi1

  • 1Department of Neurology, Higashiosaka City Medical Center.

Rinsho Shinkeigaku = Clinical Neurology
|July 8, 2026
PubMed
Summary

This study reports a rare case of limbic encephalitis associated with contactin-associated protein 2 (Caspr2) antibodies, where glial fibrillary acidic protein alpha (GFAPα) antibodies likely contributed to white matter lesions. Immunotherapy showed significant clinical and radiological improvement.

Keywords:
Caspr2 antibodyGFAPα antibodyautoimmune limbic encephalitis

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