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Related Experiment Video

Updated: Jul 10, 2026

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method
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A Rat Model of Central Fatigue Using a Modified Multiple Platform Method

Published on: August 14, 2018

A Within-Subject Model of Hot Flash-Like Symptoms in Aged Rats.

Yoshinori Okamoto1, Akira Aoki1, Shinya Shibutani2

  • 1Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.

Biological & Pharmaceutical Bulletin
|July 8, 2026
PubMed
Summary

A new monitoring system accurately measures hot flash-like symptoms in aged rats by tracking tail skin temperature. This method, using estrogen levels, offers a reliable way to study menopausal vasomotor dysfunction.

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Area of Science:

  • Reproductive Endocrinology
  • Thermoregulation Research
  • Rodent Models for Menopause

Background:

  • Hot flashes are common vasomotor symptoms (VMS) in postmenopausal women.
  • Tail skin temperature (TST) in rodents can model VMS, but requires low-stress, continuous monitoring.
  • Aged rats are underutilized in VMS research despite physiological relevance.

Purpose of the Study:

  • To establish a reliable, unrestrained monitoring system for assessing VMS-like symptoms in aged rats.
  • To evaluate the impact of estrogen on thermoregulation and circadian TST patterns in a within-subjects design.
  • To validate a rodent model for studying menopausal vasomotor dysfunction and screening therapeutics.

Main Methods:

  • Developed a system for long-term, unrestrained TST monitoring in aged Wistar rats.
Keywords:
aged ratestrogenhormone replacement therapyovariectomyvasomotor symptom

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Last Updated: Jul 10, 2026

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method
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  • Utilized a within-subjects design across four physiological states: intact, ovariectomized (OVX), 17β-estradiol (E2) treatment, and E2 withdrawal.
  • Quantified TST and ΔTST (light- vs. dark-phase difference) to assess thermoregulatory changes.

    • Main Results:

    • 17β-estradiol (E2) treatment significantly decreased dark-phase TST compared to OVX state.
    • E2 treatment reversed the increased dark-phase TST observed after OVX.
    • E2 treatment markedly increased ΔTST, indicating estrogen-dependent restoration of circadian TST amplitude.

    Conclusions:

    • The developed monitoring system enables reliable, long-term TST assessment in unrestrained rats.
    • This model provides a physiologically relevant platform for studying menopausal vasomotor dysfunction.
    • The system is suitable for investigating VMS pathophysiology and screening hot flash-targeting compounds.