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Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Direct Allylic C(sp3)-H Amination of Unactivated Olefins with Sulfonamides by Organocatalysis under Visible Light
Chen Kang1, Fei Wu1, Chang-Zhi Zhou1
1School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, Jiangxi 330031, P. R. China.
Abstract:
Herein we report the use of photoredox and organic catalysis to accomplish the C(sp3)-H amination of unactivated olefins with sulfonamides, enabling efficient access to allylic amine products with high E-selectivity. The protocol does not require a metal catalyst or prefunctionalization of the coupling partners, and it features mild conditions and functional group tolerance as evidenced by >60 examples. A preliminary mechanistic study uncovered that the transformation involved radical-radical coupling of an allylic radical with a N-centered radical under visible light irradiation.
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