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Position Statement on Rho(d) Immune Globulin Administration in the First Trimester
Fertility and Sterility
|July 8, 2026
Summary
The American Society for Reproductive Medicine (ASRM) endorses updated guidelines for administering Rho(d) immune globulin during the first trimester of pregnancy. This ensures optimal care for Rh-negative individuals.
Area of Science:
- Obstetrics and Gynecology
- Reproductive Medicine
- Immunology
Background:
- Rh(d) immune globulin is crucial for preventing hemolytic disease of the newborn in Rh-negative women.
- First-trimester management of Rh-negative pregnancies requires specific protocols.
- Previous guidelines may not reflect the latest clinical evidence.
Purpose of the Study:
- To communicate ASRM's endorsement of the 2024 ACOG practice update.
- To highlight key recommendations for Rho(d) immune globulin administration in early pregnancy.
- To promote adherence to evidence-based obstetric care.
Main Methods:
- Review and endorsement of the 2024 American College of Obstetricians and Gynecologists (ACOG) Clinical Practice Update.
- Analysis of recommendations concerning Rho(d) immune globulin prophylaxis.
- Dissemination of ASRM's supportive stance.
Main Results:
- ASRM officially supports the ACOG's 2024 recommendations.
- The endorsed guidelines provide updated protocols for Rho(d) immune globulin use.
- These recommendations address specific scenarios in the first trimester.
Conclusions:
- The ASRM's endorsement signifies agreement with current best practices for Rh(d) immune globulin.
- Adherence to these guidelines is expected to improve outcomes for Rh-negative pregnancies.
- This supports standardized and effective obstetric care from the first trimester.
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