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Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
Published on: June 6, 2025
ProBIOPSY: A Multidisciplinary International Consensus on Standards for Prostate Biopsy
Daria Chernysheva1, Francesco Di Bello2, Giulio Avesani3
1Fundació Puigvert, Dept. of Oncological Urology, Barcelona, Spain; Institut de Recerca Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
European Urology
|July 8, 2026
Summary
Standardizing prostate biopsy techniques improves local treatment planning. A consensus project harmonized magnetic resonance imaging (MRI) and biopsy strategies, though tailored approaches remain crucial for specific decisions.
Area of Science:
- Urology
- Medical Imaging
- Oncology
Background:
- Prostate biopsy lacks standardization in patient selection, tools, technique, and strategy, impacting treatment planning.
- An international consensus project aimed to harmonize these critical aspects of prostate biopsy.
Purpose of the Study:
- To establish a standardized framework for prostate biopsy procedures.
- To harmonize diagnostic pathways and biopsy strategies for improved prostate cancer management.
Main Methods:
- Systematic review and a modified Delphi process involving 34 international experts over three rounds.
- Iterative revision of 96-112 statements per round, with consensus assessed using a modified RAND appropriateness method.
Main Results:
- Consensus achieved on 29 of 36 stems (81%).
- Endorsement of biparametric and multiparametric MRI (magnetic resonance imaging) with adequate quality.
- Harmonization of targeted plus perilesional biopsy schemes for treatment planning, with acknowledgment of the need for contralateral sampling in specific cases.
Conclusions:
- The ProBIOPSY consensus provides a contemporary, standardized framework for prostate biopsy.
- Targeted biopsy strategies are sufficient for most scenarios, but no single approach fits all treatment decisions.
- Indication-specific biopsy tailoring remains essential for optimal patient care.
