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Related Experiment Video

Updated: Jul 10, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Mast Cells in the Developing Brain.

Matthew R Bruce¹, Anna A Maximova^2,3, Kaliroi J Engel²

¹Department of Pharmacology and Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201 matthewbruce@som.umaryland.edu.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|July 8, 2026

Summary

Mast cells (MCs) in the developing brain influence neurodevelopment through immune cell interactions. Understanding MCs is crucial for neurodevelopmental disorders (NDDs) and neurological disease susceptibility.

Keywords:

NDD mast cells microglia neuroimmune rodent models

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Last Updated: Jul 10, 2026

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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

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Published on: May 27, 2015

Area of Science:

Neuroscience
Immunology
Developmental Biology

Background:

Mast cells (MCs) are immune cells found in the central nervous system (CNS).
MCs show dynamic changes during brain development.
MCs interact with microglia and affect blood-brain barrier permeability.

Purpose of the Study:

To review current knowledge of mast cell biology in the developing brain.
To identify gaps in understanding MCs' role in neurodevelopment.
To explore MCs' link to neurodevelopmental disorders (NDDs).

Main Methods:

Literature review of existing research on mast cells in the CNS.
Synthesis of data on MCs' interactions with other brain cells.
Analysis of clinical and epidemiological links between MCs and NDDs.

Main Results:

CNS mast cells influence neurodevelopmental processes.
Bidirectional communication between MCs and microglia is observed.
MC mediators are implicated in NDD etiology.

Conclusions:

Further research is needed to fully understand MCs' role in brain development.
MCs may be a key factor in neurological disease susceptibility.
Investigating MCs offers potential insights into NDDs.