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Updated: Jul 10, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed Enantioselective C-H Activation Reaction of Undirected Arenes with Cyclopentenes
Shao-Bai Yan1, Meng-Meng Lu1, Qiong-Yao Gong1
1College of Chemistry and Chemical Engineering, Inner Mongolia University, 49 Xilinguole South Road, Hohhot 010020, China.
Abstract:
Although directed C-H activation has revolutionized organic synthesis, the asymmetric functionalization of arenes in the absence of directing groups remains a formidable challenge. Here we show that a palladium-catalyzed C-H activation reaction enables the enantioselective coupling of undirected arenes and heteroarenes with cyclopentene derivatives. Facilitated by a class of readily accessible chiral pyridone-oxazoline ligands, this protocol promotes efficient C(sp2)-H activation to generate the products featuring two stereocenters with excellent stereocontrol (up to 96% ee and 40:1 dr).
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