Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cancer as a Hidden Catalyst: Rethinking Postoperative Atrial Fibrillation After Cardiac Surgery.

Journal of clinical medicine·2026
Same author

Robotic-Assisted Thoracic Surgery in the Immunotherapy Era: Navigating Altered Anatomy, Oncologic Precision, and the Future of Integrated Platforms.

Journal of clinical medicine·2026
Same author

The Legacy of the First Valve: Outcomes of Redo Surgical Aortic Valve Replacement After Prior Transcatheter Versus Prior Surgical Aortic Valve Replacement-A Narrative Review.

Journal of clinical medicine·2026
Same author

Sotatercept as an Add-On to Background Therapy in Idiopathic Pulmonary Arterial Hypertension: Insights from a Real-World Cohort.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Artificial Intelligence-Driven Hypertension Management: Implications for Quality Improvement and Prevention of End-Organ Damage.

Life (Basel, Switzerland)·2026
Same author

Acute Aortic Dissection in Women: A Comprehensive Review of Sex-Specific Differences, Clinical Management, and Outcomes.

Journal of cardiovascular development and disease·2026

Related Experiment Video

Updated: Jul 10, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Heart Failure Through the Lens of Complexity.

Dirk L Brutsaert1, Andrew Xanthopoulos2, Filippos Triposkiadis3

  • 1Professor Emeritus, University of Antwerp, Belgium, Beekboshoek 204, 2550 Kontich-Waarloos, Belgium,

American Journal of Physiology. Heart and Circulatory Physiology
|July 8, 2026
PubMed
Summary

Heart failure (HF) is reframed using complexity science, exploring quantum and evolutionary biology. New theoretical models offer insights but face challenges in clinical application for managing this complex condition.

Keywords:
ChaosComplexityEvolutionary BiologyHeart FailureNonequilibrium ThermodynamicsQuantum BiologySystems Biology

Related Experiment Videos

Last Updated: Jul 10, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Area of Science:

  • * Integrates complexity science, including quantum biology, evolutionary biology, non-equilibrium thermodynamics, chaos theory, and systems biology.
  • * Applies theoretical constructs like quantum oxidative stress to understand bioenergetic decline in heart failure.

Background:

  • * Traditional reductionist approaches have limitations in fully explaining the complex pathophysiology of heart failure (HF).
  • * HF is a systemic syndrome where the myocardium cannot maintain adequate cardiac output.

Purpose of the Study:

  • * To examine heart failure through the lens of complexity science.
  • * To explore novel theoretical frameworks for understanding HF's multifaceted nature.

Main Methods:

  • * Theoretical examination of HF using principles from quantum biology, evolutionary biology, thermodynamics, chaos theory, and systems biology.
  • * Analysis of concepts such as quantum oxidative stress, dissipative structures, and loss of physiological chaos.

Main Results:

  • * Theoretical models suggest quantum oxidative stress impacts bioenergetic decline and HF.
  • * Evolutionary perspectives highlight potential lack of redundancy in the heart for modern stressors.
  • * Thermodynamic and chaos theory models characterize the heart as a dissipative structure, with HF representing a loss of physiological chaos.

Conclusions:

  • * Reframing HF as a failure of organized complexity offers a new conceptual model.
  • * Significant translational barriers exist in applying these abstract physics concepts to clinical practice.
  • * Bridging abstract physics and clinical physiology may reveal novel pathways for HF understanding and management.