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Updated: Jul 10, 2026
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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
FAPI: a solution to all, what about NENs?
Ozgul Ekmekcioglu1, Filiz Celik2, Simon Hughes3
1Nuclear Medicine Department, Yeditepe University Medical Faculty, Kosuyolu, Istanbul, Türkiye. ozgulek@gmail.com.
Abstract:
Fibroblast activation protein (FAP)-targeted PET imaging is an emerging technique that images the tumor stroma by targeting cancer-associated fibroblasts, offering high tumor-to-background contrast and improved lesion detection in tumors with low [¹⁸F]FDG avidity. Given the central role of CAFs in tumor progression and therapy response, FAPI PET has gained interest in neuroendocrine neoplasms (NENs), where stromal imaging may provide complementary information to conventional modalities. This review evaluates the biological rationale, current evidence, and potential clinical role of FAPI PET in the imaging and management of NENs.
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