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The evolution of nonlinear mixed effects modeling in pharmacometrics: toward AI-based variational autoencoders

Jan Rohleff1, Gilbert Koch2, Johannes Schropp3

  • 1Department of Mathematics and Statistics, University of Konstanz, Konstanz, Germany.

Journal of Pharmacokinetics and Pharmacodynamics
|July 8, 2026
PubMed
Abstract

Keywords:
Artificial IntelligenceFirst-Order Conditional EstimationMachine LearningNonlinear Mixed Effects ModelingStochastic Approximation Expectation MaximizationVariational Autoencoder

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