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Updated: Jul 10, 2026
08:53
Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Nasopharyngeal classical Hodgkin lymphoma: a case report
Suhaib Eid1, Somaya Al Kiswani2, Hossam Salameh3
1ENT Department, Arab Medical Center, Amman, Jordan.
Journal of Medical Case Reports
|July 9, 2026
Summary
Primary nasopharyngeal Hodgkin lymphoma is rare and can mimic common conditions, delaying diagnosis. This case shows successful treatment with chemotherapy and radiotherapy for this extranodal lymphoma.
Area of Science:
- Oncology
- Pathology
- Otolaryngology
Background:
- Hodgkin lymphoma typically originates in lymph nodes.
- Extranodal involvement, especially in the nasopharynx, is rare.
- Nasopharyngeal Hodgkin lymphoma can present with symptoms mimicking common nasal conditions, leading to diagnostic delays.
Purpose of the Study:
- To report a rare case of primary nasopharyngeal Hodgkin lymphoma.
- To highlight diagnostic challenges and treatment outcomes for extranodal Hodgkin lymphoma.
- To emphasize the importance of histopathological evaluation for persistent nasal symptoms.
Main Methods:
- A case presentation of a 51-year-old woman with progressive nasal obstruction.
- Endoscopic examination revealing a nasopharyngeal mass.
- Histopathological confirmation of lymphocyte-rich classical Hodgkin lymphoma, staged IIA.
Main Results:
- The patient received four cycles of ABVD chemotherapy followed by involved-site radiotherapy (30.6 Gy in 17 fractions).
- Complete resolution of the nasopharyngeal lesion was achieved.
- The patient remained disease-free with full recovery at 12-month follow-up.
Conclusions:
- Primary nasopharyngeal Hodgkin lymphoma presents diagnostic challenges due to its rarity and non-specific symptoms.
- A broad differential diagnosis and prompt histopathological assessment are crucial for timely diagnosis.
- Combined chemotherapy and radiotherapy are effective treatment modalities for this condition.
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