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Published on: June 18, 2021
Continuous versus intermittent lumbar CSF drainage in aneurysmal arachnoid hemorrhage: a prospective, randomized
Kuangyang Yu1, Wen Tan1, Lu Jiang1
1Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, NO.25 of Taiping Street, Luzhou, Sichuan, 646000, China.
Trials
|July 9, 2026
Summary
This randomized trial compares continuous versus intermittent lumbar drainage for hydrocephalus after aneurysmal subarachnoid hemorrhage (aSAH). It assesses neurological outcomes, shunt dependency, and mortality to guide treatment strategies.
Area of Science:
- Neurosurgery
- Neurology
- Critical Care Medicine
Background:
- Hydrocephalus is a frequent complication of aneurysmal subarachnoid hemorrhage (aSAH), leading to significant neurological deficits and mortality.
- Effective management of post-aSAH hydrocephalus is crucial for improving patient outcomes.
Purpose of the Study:
- To compare the safety and effectiveness of continuous versus intermittent lumbar drainage (LD) for managing hydrocephalus post-aSAH.
- To evaluate the impact of different LD methods on neurological prognosis, including modified Rankin Scale (mRS) and Glasgow Outcome Scale (GOS) scores.
- To determine variations in the incidence of shunt-dependent hydrocephalus and 30-day mortality between continuous and intermittent LD groups.
Main Methods:
- A prospective, single-center, randomized controlled trial with 256 patients diagnosed with aSAH.
- Patients will be randomized (1:1) to either continuous LD or intermittent LD groups within 72 hours of surgical treatment.
- Primary outcomes include mRS and GOS scores at 180 days, shunt-dependent hydrocephalus incidence, and 30-day mortality. Follow-up duration is at least 180 days.
Main Results:
- This section will report on the comparative efficacy and safety of continuous versus intermittent lumbar drainage in patients with post-aSAH hydrocephalus.
- Results will detail differences in neurological recovery (mRS, GOS), need for shunting, and short-term survival rates.
- The study aims to provide robust data on patient outcomes based on the chosen lumbar drainage method.
Conclusions:
- This trial will elucidate the optimal lumbar drainage strategy for hydrocephalus following aSAH.
- Findings are expected to inform clinical decision-making, potentially reducing neurological dysfunction and mortality associated with this complication.
- The study seeks to provide high-quality evidence for the management of hydrocephalus in aSAH patients.
