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Updated: Jul 10, 2026

Interlinked Macroporous 3D Scaffolds from Microgel Rods
07:32

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Published on: June 16, 2022

Wharton's Jelly-Derived Hybrid Scaffolds for Tissue Engineering Applications.

Claudio Nastruzzi1

  • 1Dipartimento di Scienze Chimiche, Farmaceutiche e Agrarie, Università di Ferrara, Ferrara, Italy.

Macromolecular Bioscience
|July 9, 2026
PubMed
Summary

Decellularized Wharton's Jelly (DWJ) combined with polymers creates advanced hybrid scaffolds. These bio-instructive systems enhance tissue repair for cartilage, bone, and neural applications.

Keywords:
3D bioprintingalginate hybrid scaffoldsdecellularized extracellular matrix (dECM)exosome deliverytissue engineeringwharton's jelly

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Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
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Published on: October 3, 2014

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Last Updated: Jul 10, 2026

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Published on: June 16, 2022

Three-dimensional Biomimetic Technology: Novel Biorubber Creates Defined Micro- and Macro-scale Architectures in Collagen Hydrogels
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Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

Area of Science:

  • Regenerative Medicine
  • Biomaterials Engineering
  • Tissue Engineering

Background:

  • Neonatal Wharton's Jelly (WJ) is a rich source of bioactive molecules for tissue repair.
  • Extracellular matrix (ECM) mimics are key in acellular, bio-instructive regenerative medicine strategies.
  • Decellularized Wharton's Jelly (DWJ) offers a biomimetic environment but lacks mechanical strength.

Purpose of the Study:

  • Analyze decellularized Wharton's Jelly (DWJ) integration into hybrid scaffold systems.
  • Focus on engineering alginate-based composites for enhanced tissue regeneration.
  • Highlight advancements in smart bio-instructive systems for cell-free tissue repair.

Main Methods:

  • Utilizing 3D bioprinting, microencapsulation, and lyophilization to create WJ-polymer composites.
  • Developing hybrid scaffolds by combining DWJ with tunable polymers.
  • Integrating WJ-derived exosomes and stimuli-responsive elements into advanced systems.

Main Results:

  • WJ-polymer synergy overcomes mechanical limitations of standalone DWJ scaffolds.
  • Hybrid scaffolds exhibit tunable degradation and structural integrity.
  • Emerging smart systems coordinate in situ cell-free tissue repair.

Conclusions:

  • WJ-hybrid platforms show potential as next-generation therapeutic tools.
  • These scaffolds are promising for cartilage, bone, neural, and intervertebral disc regeneration.
  • The study emphasizes the translational potential of advanced WJ-based regenerative strategies.