Related Experiment Video

Updated: Jul 10, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

Midwall Late Gadolinium Enhancement and Native T1 Elevation in Chronic Myocarditis-Related Dilated Cardiomyopathy: An

Praveen Septian Hadi1, Dimas Adjie Yuda Mahendra2, Johan Gunadi3

  • 1General Practitioner, Dr. Loekmono Hadi General Hospital, Kudus, Central Java, Indonesia. praveenseptianh@gmail.com.

Acta Medica Indonesiana
|July 9, 2026
PubMed

Insights

Cardiovascular magnetic resonance (CMR) accurately diagnoses chronic myocarditis and dilated cardiomyopathy (DCM). Advanced CMR techniques like late gadolinium enhancement (LGE) and T1 mapping predict adverse outcomes, guiding personalized patient management.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Cardiovascular magnetic resonance (CMR) is the gold standard for non-invasive myocardial tissue characterization.
  • CMR is crucial for diagnosing and predicting outcomes in myocarditis and non-ischemic dilated cardiomyopathy (DCM).

Purpose of the Study:

  • To present a case of chronic myocarditis/DCM.
  • To integrate this case with evidence on CMR's diagnostic and prognostic utility.

Main Methods:

  • An evidence-based case report (EBCR) framework was used.
  • Systematic literature search across PubMed, Cochrane Library, and ScienceDirect.
  • Studies evaluated CMR in myocarditis or DCM using 2018 Lake Louise Criteria or equivalent protocols.

Main Results:

  • A patient presented with CMR findings of midwall LGE, elevated native T1, and no T2 elevation, indicating chronic injury and fibrosis.
  • Midwall LGE correlates with myocarditis, predicts mortality and sudden cardiac death, and signals risk of ventricular dysfunction.
  • Native T1 mapping enhances detection of diffuse fibrosis, aiding diagnosis in chronic myocarditis/DCM.

Conclusions:

  • CMR, using LGE and mapping, provides diagnostic clarity and prognostic information for chronic myocarditis/DCM.
  • This enables precise, individualized clinical management strategies.
  • Findings support intensified surveillance and potential device therapy for high-risk patients.
Abstract

Keywords:
Cardiovascular magnetic resonanceChronic myocarditisDilated cardiomyopathyLate gadolinium enhancementT1 mapping

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