Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

CBD-Containing Topical Formulation for Localized Pain in Fibromyalgia: A 12-Week Pilot Feasibility Study.

Tamara L Rodríguez-Araya¹, Anna Arias¹, Luciano Polino¹

¹Rheumatology Service, Institut Clínic d'Especialitats Mèdiques i Quirúrgiques, Hospital Clínic de Barcelona, Barcelona, Spain.

Cannabis and Cannabinoid Research

|July 9, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Estetrol potentiates progesterone-driven growth restraint while blunting pro-angiogenic activation in murine endometriosis lesions.

Cells & development·2026

Same author

Abatacept versus hydroxychloroquine for prevention of rheumatoid arthritis in individuals with palindromic rheumatism: a randomized open-label trial.

Nature medicine·2026

Same author

Response of ultrasound-assessed synovitis to baricitinib, in monotherapy and combined with methotrexate, compared with etanercept in rheumatoid arthritis: a randomised, international, multicentre trial.

Annals of the rheumatic diseases·2026

Same author

The Challenge of Hypophosphatasia Diagnosis in Patients with Fibromyalgia.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre·2025

Same author

Efficacy and safety of pregabalin in the management of low back pain: a comprehensive meta-analysis.

Frontiers in pharmacology·2025

Same author

The development of a Community Service Announcement to raise awareness of the Home Medicines Review health service program.

Australasian journal on ageing·2025

This summary is machine-generated.

A topical cannabidiol (CBD) formulation showed feasibility and safety for localized pain in fibromyalgia patients. This pilot study suggests potential benefits for localized pain and function, warranting further research.

Area of Science:

Pain Management
Cannabinoid Therapeutics
Rheumatology

Background:

Fibromyalgia (FM) is a chronic pain condition with limited treatment options.
Cannabidiol (CBD) exhibits analgesic and anti-inflammatory properties.
Evidence for topical CBD in FM is scarce.

Purpose of the Study:

Evaluate feasibility, safety, and preliminary efficacy of topical CBD for localized pain in FM.
Explore CBD's impact on broader fibromyalgia symptom domains.

Main Methods:

Single-arm pilot study with 30 women with FM and localized pain.
Participants applied a CBD topical formulation every 8 hours for 12 weeks.
Assessed outcomes at baseline, 4, and 12 weeks using nonparametric analyses and MCID thresholds.

Keywords:

CBD-containing topical formulation cannabidiol chronic pain fibromyalgia nonopioid analgesics peripheral sensitization

Related Experiment Videos

Last Updated: Jul 10, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

Main Results:

Full adherence and no adverse events reported.
Significant and clinically meaningful reduction in localized pain sustained at 12 weeks.
Improved functional capacity and decreased WPI and SSS scores; fewer participants met ACR criteria at 12 weeks.

Conclusions:

Topical CBD formulation is feasible and improves localized pain and function in FM.
Observed changes in WPI, SSS, and ACR criteria are exploratory due to study design.
Pilot study provides data for future randomized controlled trials on topical cannabinoids for FM.