Related Experiment Video
Updated: Jul 10, 2026
13:22
Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
Olverembatinib: real progress in BCR::ABL1 leukemia?
Vivian G Oehler1, Ariel Leyte-Vidal2, Ivan J Huang3
1Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Medicine, Division of Hematology and Oncology, University of Washington, Seattle, WA. voehler@fredhutch.org.
Haematologica
|July 9, 2026
Summary
Olverembatinib is a third-generation tyrosine kinase inhibitor effective against resistant chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It shows promise for patients with T315I mutations and those resistant to other TKIs.
Area of Science:
- Oncology
- Pharmacology
- Hematology
Background:
- Chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) are driven by BCR::ABL1.
- Tyrosine kinase inhibitors (TKIs) are standard treatments, but resistance, particularly the T315I mutation, necessitates novel therapies.
- Olverembatinib (HQP1351) is a third-generation TKI designed to overcome resistance mechanisms.
Purpose of the Study:
- To review the safety, tolerability, and efficacy of olverembatinib in CML and Ph+ ALL.
- To evaluate olverembatinib's role in treating TKI-resistant CML, including T315I mutations.
- To discuss the potential of olverembatinib in first-line Ph+ ALL treatment.
Main Methods:
- Review of clinical trial data from China and ongoing global studies (including US Phase 1b).
- Analysis of safety and efficacy endpoints in adult patients with CML and Ph+ ALL.
- Assessment of olverembatinib's binding to active and inactive conformations of ABL1 and BCR::ABL1.
Main Results:
- Olverembatinib is approved in China for TKI-resistant CML (CP/AP) with T315I mutation and for imatinib/2G TKI-resistant CP CML.
- Received breakthrough therapy designation for first-line Ph+ ALL in combination with chemotherapy.
- Global clinical studies are ongoing, with US Phase 1b results anticipated in 2025.
Conclusions:
- Olverembatinib demonstrates significant efficacy and tolerability in TKI-resistant CML and Ph+ ALL.
- It represents a crucial therapeutic option for patients with resistance mutations like T315I.
- Further global data will solidify its role in hematologic malignancies and guide future development.
Related Concept Videos
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...