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Updated: Jul 10, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists
Published on: July 18, 2025
Continuous carbon dioxide flow via a modified 4-way stopcock to prevent hemostatic spray catheter clogging
Mina Alkomos1, Dhruv Patel1, Islam Rajab2
1Gastroenterology Department, St Joseph's University Medical Center, Paterson, New Jersey, USA.
Background And Aims:
Clogging of the Hemospray catheter (TC-325 Hemospray; Cook Medical, Bloomington, Ind, USA) is a common technical challenge, particularly when the tip becomes wet during endoscopic procedures, leading to interruption of hemostasis. A prior solution described a modified airflow connection to prevent occlusion. We developed a simplified, reproducible method using commercially available carbon dioxide (CO2) insufflation devices and tubing, connected via a 4-way stopcock to provide continuous CO2 flow through the Hemospray catheter.
Methods:
The assembly incorporated commercially available CO2 insufflation devices and tubing, a 4-way stopcock, and the standard Hemospray system. Continuous CO2 flow was maintained throughout the procedure to displace moisture and preserve lumen patency.
Results:
Continuous CO2 flow effectively prevented catheter occlusion and maintained uninterrupted spray function even after fluid contact. The demonstration confirmed consistent delivery without clogging.
Conclusions:
This 4-way stopcock enables continuous CO2 flow through the Hemospray catheter, preventing clogging in a simple, low-cost, and reproducible manner. The set-up is readily adaptable to existing endoscopic systems and may enhance procedural efficiency and device reliability.
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