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Investigating association of triglycerides with hemodynamic parameters in patients with Low cardiovascular risk using
Weiling Wang1, Shuangqi Fu1, Yong Xiang1
1Department of Radiology, Guiqian International General Hospital, Guiyang, Guizhou, China.
Insights
High triglycerides (TG) are linked to altered carotid wall shear stress (WSS) in younger adults. Severely elevated TG levels significantly increased WSSmax and WSSmean in the internal carotid artery (ICA-1) segment.
Area of Science:
- Cardiovascular medicine
- Medical imaging
- Biomedical engineering
Background:
- Cardiovascular disease (CVD) is a major global health concern.
- Hypertriglyceridemia is a significant risk factor for CVD.
- The impact of triglycerides on carotid hemodynamics in low-risk individuals is not well understood.
Purpose of the Study:
- To investigate the association between triglyceride levels and carotid hemodynamics.
- To assess wall shear stress (WSS) parameters in relation to varying triglyceride concentrations.
- To explore these relationships in a population with low cardiovascular risk.
Main Methods:
- Prospective study of 106 participants (aged ≤55 years) with low cardiovascular risk.
- Categorization into normal, elevated, and severely elevated triglyceride groups.
- 4D Flow MRI used to measure carotid hemodynamics, including WSSmax and WSSmean in the ICA-1 segment.
Main Results:
- Severely elevated triglyceride levels were associated with significantly higher WSSmax and WSSmean in the ICA-1 segment compared to normal and elevated TG groups (p < 0.001).
- Triglycerides remained an independent predictor of WSSmax (B=0.010, p < 0.001) and WSSmean (B=0.004, p = 0.004) after adjusting for covariates.
- No significant differences in WSS were observed between normal and elevated TG groups.
Conclusions:
- Triglyceride levels are independently associated with carotid WSS parameters.
- Severely elevated triglycerides notably impact WSS in the internal carotid artery.
- Findings highlight potential hemodynamic alterations contributing to cardiovascular risk even in younger, low-risk individuals.
Introduction:
Cardiovascular disease (CVD) remains a global health challenge, with hypertriglyceridemia as a key risk factor. The relationship between triglycerides (TG) and carotid hemodynamics in low-risk populations is unclear.
Materials And Methods:
This prospective study enrolled 180 participants aged 55 years or younger with low cardiovascular risk. Participants were divided into three groups based on TG levels: normal TG (<1.7 mmol/L), elevated TG (1.7-5.64 mmol/L), and severely elevated TG (≥5.65 mmol/L). 4D Flow MRI data were acquired using a 3 T MRI scanner, and hemodynamic parameters were measured. Statistical analysis included the Mann-Whitney U-test, Kruskal-Wallis H-test, ANOVA, mixed-effects models, and multiple linear regression.
Results:
A total of 106 participants (mean age 37.05 ± 8.17 years, 62 males) were included. Significant differences in WSS-related parameters, particularly WSSmax and WSSmean, were observed across TG groups. In the RICA-1 segment, for normal TG, WSSmax (0.29 ± 0.10 Pa) and WSSmean (0.20 ± 0.06 Pa) were similar to those in the elevated TG group (WSSmax: 0.29 ± 0.10 Pa, WSSmean: 0.20 ± 0.06 Pa). In the severely elevated TG group, WSSmax (0.44 ± 0.14 Pa) and WSSmean (0.28 ± 0.08 Pa) were significantly higher than in the other groups (p < 0.001). Similar differences were observed in the LICA-1 segment. In mixed-effects models adjusting for age, sex, total cholesterol, HDL-C, BMI, and smoking status, TG remained independently associated with WSSmax (B = 0.010, p < 0.001) and WSSmean (B = 0.004, p = 0.004).
Conclusion:
Our study demonstrates that TG levels are independently associated with carotid WSS parameters after comprehensive covariate adjustment, with the most pronounced changes in the ICA-1 region among individuals with severely elevated TG.
Clinical Trial Registration:
https://www.chictr.org.cn/showprojEN.html?proj=224462, ChiCTR2400082465.
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