Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

Immunocompetent Intestine-on-Chip Model for Analyzing Gut Mucosal Immune Responses

Immunocompetent Intestine-on-Chip Model for Analyzing Gut Mucosal Immune Responses

Published on: May 24, 2024

Microfluidic Gut-on-a-Chip Models for Functional Food Evaluation: From Digestion Kinetics to Personalized Nutrition.

Feng Yao¹, Lichun Chen¹

¹Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China.

Comprehensive Reviews in Food Science and Food Safety

|July 9, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development and validation of a dual-attention deep learning prediction model for noninvasive differentiation of pulmonary invasive mucinous adenocarcinoma from inflammatory pulmonary nodules.

Translational lung cancer research·2026

Same author

AdipoRon ameliorates synovial inflammatory lesions and joint destruction in experimental arthritis by downregulating KRT7.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026

Same author

Trastuzumab emtansine versus trastuzumab plus pertuzumab for HER2-positive breast cancer with residual disease after neoadjuvant therapy: a real-world study.

Frontiers in oncology·2026

Same author

PSMD8 promotes breast cancer progression and attenuates paclitaxel sensitivity by stabilizing KIF10.

Cancer cell international·2026

Same author

HMGCS1 drives cholesterol-dependent membrane repair and shields tumor cells from lymphocyte attack.

Nature communications·2026

Same author

Fibroblast-derived HSD11B1 deficiency drives lung cancer in never-smokers through steroid metabolic imbalance.

NPJ precision oncology·2026

Microfluidic gut-on-a-chip (GOC) technology offers a biomimetic platform for assessing functional food ingredients. This advanced system bridges the gap between traditional lab tests and human studies, improving the evaluation of food bioactives.

Area of Science:

Gastroenterology and Bioengineering
Functional Food Science
Microphysiological Systems

Background:

Accurate assessment of functional food ingredient gastrointestinal fate is crucial for health benefit claims.
Conventional in vitro models lack the dynamic, multicellular, and physicochemical complexity of the human intestine, leading to a predictive gap.
Microfluidic gut-on-a-chip (GOC) technology offers a biomimetic microphysiological approach.

Purpose of the Study:

To critically review the applications of GOC systems in evaluating food bioactives.
To summarize core GOC design principles and discuss their relevance to food science.
To analyze the advantages, limitations, and industrial translation pathways for GOC technology in functional food development.

Main Methods:

Keywords:

bioavailability functional food ingredients gut‐on‐a‐chip in vitro digestion intestinal absorption personalized nutrition

More Related Videos

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

Related Experiment Videos

Last Updated: Jul 10, 2026

Immunocompetent Intestine-on-Chip Model for Analyzing Gut Mucosal Immune Responses

Immunocompetent Intestine-on-Chip Model for Analyzing Gut Mucosal Immune Responses

Published on: May 24, 2024

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

Review of GOC system design principles (biomimetic architecture, materials, mechanical cues, gradients).

Discussion of GOC applications: sequential digestion, absorption, barrier function, host-microbiota interactions, disease modeling, personalized nutrition.

Analysis of GOC system advantages (physiological relevance, real-time monitoring) and limitations (analytical bias, variability, scalability).

Main Results:

GOC systems integrate fluid flow, mechanical cues, and multicellular co-cultures for biomimicry.
Applications span digestion, absorption, barrier assessment, host-microbiota dynamics, and personalized nutrition.
Key considerations for translation include throughput, standardization, regulatory acceptance, and scalability.

Conclusions:

GOC technology provides a promising platform for evaluating food bioactives, enhancing physiological relevance.
The technology can support high-throughput screening, personalized formulation testing, and multi-organ assessments.
GOC systems have the potential to bridge conventional assays and human studies for evidence-based functional food development.